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Laser Speckle Imaging System



 Overview

A Laser Speckle Imaging System is a non-invasive optical imaging technology used to visualize and quantify real-time blood flow and microcirculation in biological tissues. It is widely applied in biomedical research, neuroscience, vascular studies, dermatology, and preclinical imaging.

How Laser Speckle Imaging Works

When coherent laser light illuminates biological tissue, it scatters and forms a random interference pattern known as speckle.

  • Static tissue produces a stable speckle pattern

  • Moving particles (such as red blood cells) cause fluctuations in the speckle pattern

By analyzing these fluctuations, the system generates high-resolution maps of tissue perfusion and blood flow dynamics.

Key Features

  • Real-time imaging of blood flow

  • Non-contact & non-invasive

  • High temporal and spatial resolution

  • Wide field-of-view imaging

  • Quantitative perfusion analysis

  • Fast data acquisition and processing

Applications

  • Neuroscience: cerebral blood flow monitoring

  • Cardiovascular research: microvascular perfusion studies

  • Dermatology: skin blood flow assessment

  • Ophthalmology: retinal and choroidal circulation

  • Wound healing & burns research

  • Preclinical and translational research

Advantages of Laser Speckle Imaging

  • No contrast agents required

  • Suitable for longitudinal studies

  • Sensitive to microvascular changes

  • Simple experimental setup

  • Ideal for live imaging and functional studies

Typical System Components

  • Coherent laser light source

  • High-speed scientific camera

  • Imaging optics

  • Data acquisition & analysis software

  • Vibration-isolated platform (optional)